Conversely, Vit D, through the interaction with negative VDREs, may negatively regulate the expression of gene encoding for several pro inflammatory cytokines such as interleukin 2 IL 2 and interleukin 12 IL 12, tumor necrosis factor О± TNF О±, interferon Оі IFN Оі, and or growth factors and receptors such as epidermal growth factor receptor EGFR, c myc, and hormones involved in calcium homeostasis including parathyroid hormone PTH, parathyroid hormone related peptide PTHrP, and rel B Haussler e